Postdoctoral Research Associate

Apply now Search #: 494822
Work type: Full-time
Location: Storrs Campus
Categories: Postdoctoral Research Associates

JOB SUMMARY

A Postdoctoral Research Associate position is available in Dr. Daniel Bolnick’s research group (https://bolnicklab.wordpress.com), in the Department of Ecology and Evolution at the University of Connecticut. The postdoc will join an ongoing NIH-funded project to use CRISPR/cas9 gene editing of threespine stickleback to evaluate the phenotypic effect of candidate genes on host immune phenotypes and resistance to cestode infection. The postdoc may also begin work on a related question of how cestode genotype affects infection outcome and host phenotypes.

DUTIES AND RESPONSIBILITIES

The Postdoctoral Research Associate will combine experimental genetics with immune challenges to identify the genetic and immunological basis of rapidly-evolved population differences in stickleback immunity to a cestode parasite, and associated costly immunopathology. The Bolnick lab has identified naturally evolved heritable differences in stickleback fishes’ ability to resist infection, and suppress growth of established cestodes. This resistance entails a recently-evolved fibrosis immune response that can be experimentally studied using an artificial vaccination strategy (see https://bolnicklab.wordpress.com/2015/10/12/bolnick-lab-publications/ for recent publications concerning evolution of cestode resistance and fibrosis). Using QTL mapping, GWAS, population genomic divergence, and transcriptomics we have identified promising candidate genes potentially underlying these immunological differences. With funding from the NIH, we have successfully implemented CRISPR/cas9 gene editing of some candidate genes. The postdoc hired for this position will extend this gene editing work to encompass more replicates, more candidate genes, and evaluate the phenotypic effect of these transgenic manipulations using experimental infections and artificial vaccination assays. The work will be based at the University of Connecticut, though some field work may be necessary, such as to breed fish for lab work or to obtain cestodes. The postdoc will be responsible for conducting lab and field work, co-supervising laboratory technicians and students, data analysis and publication. Opportunities exist to pursue side-projects along with the core project task.

MINIMUM QUALIFICATIONS

  • PhD in evolutionary biology, genetics, immunology, or a closely related field
  • Prior experience with molecular genetics or immunology

PREFERRED QUALIFICATIONS

  • Previous research experience and publications should demonstrate a commitment to basic research, good work ethic, lab skills, organizational ability, and publication productivity.
  • Expertise in CRISPR/cas9 gene editing

APPOINTMENT TERMS

The position is available for up to two years, subject to annual review of performance. The position could extend longer, contingent on availability of additional grant funds. The postdoc should be able to start in spring or summer of 2021, exact dates to be negotiated with the PI.

TO APPLY

Please apply online at https://hr.uconn.edu/jobs, Staff Positions, Search #494822. Applications should electronically submit a single pdf file containing the following, in order:

  1. A statement of past research achievements, including relevant skills (1-2 pages)
  2. A statement of what you can contribute to the Bolnick Lab’s research, and how this fits into your career goals. This should not exceed one single-spaced page.
  3. A CV
  4. A copy of two publications or submitted manuscripts.
  5. A list of three references, with contact information (email, telephone, and mailing address). We will request letters directly from these references, after identifying top candidates.

An initial application should be emailed to Dr. Daniel Bolnick ( daniel.bolnick@uconn.edu ). For full consideration applicants will also need to apply via UConn Jobs.  Include the subject line "Evolutionary immune genetics Postdoc: ". Application review will begin on December 1, 2020, though late applications will be accepted until the position is filled.

Employment of the successful candidate is contingent upon the successful completion of a pre-employment criminal background check. 

This job posting is scheduled to be removed at 11:55 p.m. Eastern time on December 8, 2020. 

All employees are subject to adherence to the State Code of Ethics which may be found at http://www.ct.gov/ethics/site/default.asp.

The University of Connecticut is committed to building and supporting a multicultural and diverse community of students, faculty and staff. The diversity of students, faculty and staff continues to increase, as does the number of honors students, valedictorians and salutatorians who consistently make UConn their top choice. More than 100 research centers and institutes serve the University’s teaching, research, diversity, and outreach missions, leading to UConn’s ranking as one of the nation’s top research universities. UConn’s faculty and staff are the critical link to fostering and expanding our vibrant, multicultural and diverse University community. As an Affirmative Action/Equal Employment Opportunity employer, UConn encourages applications from women, veterans, people with disabilities and members of traditionally underrepresented populations.

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Applications close: Eastern Standard Time

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